Fatty Liver Disease: Another Reason to Avoid Obesity

An article in the January 2011 issue of the Harvard Health Letter reveals that the epidemic of obesity has increased the occurrence of fatty liver disease. Previously, most cases of fatty liver disease were related to excess alcohol consumption, but now, many cases are related to excess body fat, which can lead to Type II diabetes. Fatty liver disease affects 70-90% of those who are obese and/or have diabetes.

Abdominal obesity can lead to metabolic syndrome (elevated blood pressure and levels of triglycerides and blood sugar, and low HDL (good cholesterol). Overfilled fat cells become resistant to insulin (which lowers blood sugar by storing it in the cells) resulting in excess fatty acids in the blood. Fat then accumulates in liver cells, which can lead to inflammation and liver tissue damage.  This can in turn bring about liver fibrosis (buildup of fibrous tissue) or cirrhosis (buildup of scar tissue). Cirrhosis increases the risk of liver cancer.

Fatty liver disease increases the risk of heart attack and stroke because a fatty liver produces inflammatory factors that can promote the deposition of plaque in the arteries, leading to arterial narrowing.

The only effective treatment for fatty liver disease is to lose weight.

Bottom Line
If you want to avoid or reverse fatty liver disease, avoid gaining unnecessary body fat or lose existing excess body fat through a program of good nutrition and exercise. Both caloric restriction and exercise are essential parts of any weight-loss program.

Are There Hidden Causes of the Overweight Epidemic?

In the December 20, 2010 issue of Newsweek magazine, Sharon Begley, the magazine’s science columnist, wrote that there are some little-known factors that may contribute to the continued increase in the prevalence of overweight and obesity. Her main argument is that it must be more than a matter of exercising more and eating better because, among animals that have contact with human beings, such as pets, lab animals and rodent pests, 23 of the 24 species studied since 1940 have shown significant increases in the percentages of overweight and obese animals, a statistic that could have occurred by chance only once in 8 million. Yet changes in diet and exercise don’t appear to be the reason, as these factors haven’t changed much for these animals over the years.

Begley cites some possible reasons other than diet and exercise for the weight gain of animals and, by extension, us:

• The type of bacteria in our gut - more efficient bacteria wring more calories out of our food than do less efficient bacteria. In this case, efficiency is not our friend.
• Lack of sleep, which increases the appetite-stimulating hormone ghrelin, and decreases the hormone leptin that suppresses our appetite when we’ve eaten enough.
• Environmental chemicals such as BPA that stimulate fat-cell production.
• Home heating, which lessens the need for the body’s calorie-consuming heat production.
• Home air conditioning, which lessens the appetite-suppressing effect of environmental heat.
• Infection with adenovirus-36, which causes obesity in  lab animals and is correlated with obesity in humans.

In addition, I feel that there may be another contributor to obesity:

• The lack of internal parasites due to modern sanitary practices. If parasites eat some of our food, less of it can be packed on as fat. If they partake of our bodies, then energy must be consumed for repair. This assumes the kind of parasites that are relatively harmless other than consuming some of our food or body tissue.

Bottom Line
There is no doubt that our health benefits from exercising regularly and eating a healthy diet without excess calories. However, we must continue to look for other contributing factors in order to effectively deal with and counteract the continued rise in overweight and obesity that threatens to undermine the gains we’ve made in improving our health and increasing our lifespan.